Dead Space 2

The game begins in a hospital on the Sprawl, a densely populated metropolis built on a shard of Titan, one of Saturn's moons.^[12][13] Isaac Clarke has no memory of the last three years, having just been released by Franco, the protagonist of Dead Space Ignition. However, before he can remove the straitjacket, Franco is killed and transformed into a necromorph, leaving Isaac to escape on his own. He is later contacted by a woman named Daina, who guides him to her location. He is also contacted by another patient, Nolan Stross, claiming he and Isaac can destroy the Marker, which Hans Tiedmann, the station's administrator, forced them both to rebuild after finding Isaac adrift. Ignoring Stross, Isaac fights his way across the city, making his way to Daina. Upon his arrival, two guards seize Isaac as Daina reveals that she is a Unitologist sent to "recover" Isaac, claiming that he is responsible for building the Marker that is causing the current infestation and that they need him to build more. As they are about to leave, A Titan Security gunship guns down Daina and her associates, allowing Isaac to escape.
Stross contacts Isaac again and he reluctantly decides to trust Stross, as his only mission now is to destroy the Marker. Stross tells Isaac that the Marker is located in the Government Sector under lockdown. As he makes his way there, Isaac comes across another survivor, Ellie Langford, a CEC officer who eventually joins their mission, deciding that she needs their help to survive. As they progress through the Sprawl, Tiedemann throws several obstacles in their way to stop them from getting to the Marker. Later, Stross' dementia worsens, causing him to attack Ellie, stabbing her eye out with a screwdriver. She survives, and later Isaac is forced to kill Stross in self-defense. As he fights his way to the Marker Isaac experiences visions of Nicole, which become more vivid as she tries to deter him from his task. Eventually he comes to accept the guilt of Nicole's death, causing the Nicole visions to become friendly.
Upon reaching the Government sector, Isaac sends Ellie away alone on a gunship, despite her protests. He does this because he reasons that, even though he could not save Nicole, there is still time for him to save Ellie. Once inside, he releases the doors holding back the necromorphs trying to get to the Marker, who overwhelm Tiedemann's men. Isaac eventually comes upon the Marker, which is surrounded by necromorphs. As Isaac looks on, the Marker begins "convergence", an event foretold by the Unitologists. With the vision of Nicole guiding him, he comes upon a machine that unlocks the blocked Marker-infected parts of his mind, which Nicole claims will help him. He then fights his way to the Marker, where he encounters Tiedemann, whom Isaac is forced to kill. Isaac then approaches the Marker when the Nicole vision suddenly pulls Isaac into his own mind. There, Isaac encounters the parts affected by the Marker and the Nicole vision, who then reveals that the only way to make the Marker "whole" is to absorb the body and mind of the one who created it. After a lengthy battle, Isaac is able to destroy the Nicole vision and rid all traces of the Marker's influence from his mind, destroying the Marker in the process.
Upon exiting his mind, Isaac slumps to the ground, ready to accept his fate as, in a last act of desperation by Tiedmann's security forces, the station's power core will detonate, destroying the station. Suddenly, Isaac receives a call from Ellie, who crashes the gunship through the ceiling. As the room collapses, Isaac makes his way onto the gunship and they escape.
After the credits, an audio transmission is heard between two people, an unknown subordinate and his ranking superior (known only as "the Overseer" from one of the text logs that can be collected during the course of the game). The subordinate relays that Titan Station (which was Marker Site 12) and the Marker have been destroyed. The Overseer replies that the other sites will then have to “pick up the pieces”.

Isaac Clarke – The protagonist. Isaac is tormented by a dementia caused by self-replicating signals implanted into him before the Red Marker's destruction in the first game. No longer a silent protagonist, Isaac now speaks; Gunner Wright provides his likeness and voice.^[14]

• Hans Tiedemann - Director of Titan Station, the highest civil authority aboard the Sprawl and the game's main human antagonist. Lester Purry provides his likeness and voice.

• Ellie Langford - A CEC heavy equipment pilot and one of the few survivors of the Necromorph attack. Sonita Henry provides her likeness and voice.

• Nolan Stross - A demented survivor aboard the Sprawl. Prior to the disaster, he suffered dementia caused by exposure to the pieces of the Red Marker in Dead Space: Aftermath. Fallen to complete insanity, causing him to murder his wife and son; he was captured and transported to the Sprawl where he, alongside Isaac, underwent brainwashing under Tiedemann's psychiatric team. Curt Cornelius provides his likeness and voice.

• Daina Le Guin - A Unitologist fanatic, Daina is the first main character who contacts Isaac after his escape from the psychiatric lab. Tahyna Tozzi provides her likeness and voice.

• Nicole Brennan - Isaac's dead girlfriend appears as a hallucination caused by Isaac's dementia. Tanya Clarke provides her likeness and voice.

Multiplayer mode pits two teams of four players against each other, one team consisting of humans trying to accomplish an objective, and the other consisting of Necromorphs, who are tasked with stopping the humans from accomplishing said objective. Each playable character has two weapons in their arsenal. New weapons and improvements can be unlocked through level progression, along with different colored suits for the humans. The necromorphs on the other hand, unlock improvements to their current abilities as well as bonuses to health or damage.

The Collector's Edition of Dead Space 2 features a copy of the game, replica plasma cutter, CD soundtrack, DLC voucher (for access to the Unitology Suit and Force Gun) and artwork. In North America, all three system versions comes with the plasma cutter. In Europe, however, only the Xbox 360 and PC versions come with the plasma cutter. The PlayStation 3 version forgoes the replica gun and comes with Dead Space: Extraction, and a DLC voucher for access to the Rivet Gun.^[21] It is the HD version of Extraction which supports PlayStation Move, features co-op gameplay options, and has been updated to include full trophy support